SIGS

Experts and members from all partner sites of the WGGC have constituted 8 Special Interest Groups (SIGs), small working groups focusing on topics relevant for operational and strategic decisions by the WGGC management.

SIG 1 – Public Outreach & Knowledge Transfer

Members

Leader: Björn Usadel, RWTH
Sebahattin Cirak, UoC
Alexander Dilthey, HHU
Robert Meyer, RWTH
Lars Podsiadlowski, UBO
Alvaro Rada-Iglesias, UoC
Alfredo Ramirez, UoC
Laura Rose, HHU
Melanie Sapp, HHU
Joachim Schultze, UBO

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SIG 2 – Teaching & Career Support

Activities within SIG 2 provide career support for participating scientists as well as training opportunities for students and early career researchers.
A major goal is the training of a new generation of researchers in the field of genomic life science research. Measures include dedicated training, exchange between researchers at various levels and teaching. Specific activities comprise:

  • Young scientists genomics seminar series
  • Exchange of PhD-students and PostDocs between the partnering sites
  • Internal exchange program for bioinformaticians
  • Regular courses on data analysis tools including a 1-day Snakemake-Tutorial offered by the Köster lab (Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen)
  • WGGC Winter School in year 3
  • Student courses on genomic research to support bachelor, master and PhD programs
  • Electronic teaching material on genomic research accessible via the WGGC website
  • Provision of equal gender opportunities at all levels

Members

Leader: Dagmar Wieczorek, HHU
Thomas Eggermann, RTWH
Irene Esposito, HHU
Johannes Köster, UDE
Lena Peitzmann, HHU
Heiko Schoof, UBO
Joachim Schultze, UBO
Benjamin Stich, HHU
Björn Usadel, RTWH
Thomas Wiehe, UoC

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SIG 3 – Strategy & Science

Members

Leader: Markus Nöthen, UBO
Andreas Beyer, UoC
Arndt Borkhardt, HHU
George Coupland, MPIPZ
Alexander Dilthey, HHU
Nils Gehring, UoC
Ingo Kurth, RTWH
Bernhard Misof, UBO
Michael Nothnagel, UoC
Peter Nürnberg, UoC
Sven Rahmann, UDE
Alfredo Ramirez, UoC
Sigfried Roth, UoC
Karl Schellander, UBO
Andreas Schlitzer, UBO
Thomas Wiehe, UoC

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SIG 4 – Technology & Production

The SIG 4 harmonizes and develops lab management and NGS technology and production standards within the WGGC. All 3 core leaders of WGGC production sites as well as representatives of other high-throughput NGS labs in West Germany and researchers with distinct NGS experience work together on the following tasks.

Development & evaluation of new technologies, implementation of new protocols 

NGS is a fast evolving field and our first task is definitely our favorite one. We identify upcoming tools, share our future plans, and coordinate efficient implementation.

Exchange of experience, transfer of expertise   

Our NGS labs have complementary expertise and different foci. Within SIG 4 we cooperate on all levels from short consultations to meetings and lab rotations to deepen our know-how and expand our portfolio more effective than anyone of us could do on his own.

Sharing of SOPs, common quality management, harmonized price lists

Common applications should be standardized to allow comparability and reproducibility to improve quality of NGS data in the community.

Members

Leader: Janine Altmüller, UoC (Core leader Cologne)
Matthias Begemann, RWTH
Sebahattin Cirak, UoC
André Heimbach, UBO (Core leader Bonn)
Per Hoffmann, UBO
Bruno Huettel, MPIPZ (Max Planck-Genome-centre Cologne)
Karl Köhrer, HHU (Core leader Düsseldorf)
Florian Kraft, RWTH (NGS lab IGH Aachen)
Michal Schweiger, UoC
Achim Tresch, UoC
Björn Usadel, RWTH

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SIG 5 – Consulting

Members

Leader:Per Hoffmann, UBO
Janine Altmüller, UoC
André Heimbach, UBO
Karl Köhrer, HHU
Sven Rahmann, UDE
Andreas Schlitzer, UBO
Heiko Schoof, UBO
Michal Schweiger, UoC
Achim Tresch, UoC

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SIG 6 – Statistics & Computational Topics

The SIG 6 advises on, harmonizes and develops analysis pipelines to be used for automated (secondary) NGS data analysis within the WGGC. It also offers optional non-standard (tertiary) data analysis in collaboration with SIG members.

Standard automated data analysis

  • Secondary data analysis
  • High-throughput analysis pipelines for standard tasks
  • Includes genomics, epigenetics, RNA-seq, ChIP-seq, Long-read and single-cell sequencing
  • Covers a broad range of kingdoms & species, e.g. humans, selected animals, plants and microbes
  • Involves statistical and bioinformatic approaches

Non-standard data analysis

  • Tertiary data analysis in collaboration with one or more SIG 6 members
  • Optional, i.e. requires agreement by the SIG member(s) before the project

Members

Leader: Michael Nothnagel, UoC
Andreas Beyer, UOC
Ivan Costa, RWTH
Alexander Dilthey, HHU
Gunnar Klau, HHU
Johannes Köster, UDE
Peter Krawitz, UBO
Andreas Buness, UBO
Ruben Garrido Oter, MPIPZ
Alexander Probst, UDE
Heiko Schoof, UBO/INRES
Holger Schwender, HHU
Benjamin Stich, MPIPZ/HHU
Holger Thiele, UOC
Achim Tresch, UOC
Thomas Ulas, UBO
Thomas Wiehe, UOC

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SIG 7 – HPC & Performance Optimization

Members

Leader:Ulrich Lang, UoC
Viktor Achter, UoC
Ivan Coster, RWTH
Alexander Donath, UBO
Per Hoffmann, UBO
Gunnar Klau, HHU
Peter Krawitz, UBO
Susanne Motameny, UoC
Ruben Garrido Oter, MPIPZ
Holger Schwender, HHU
Benjamin Stich, HHU
Holger Thiele, UoC
Thomas Ulas, UBO

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SIG 8 – Data Management & Protection

The SIG 8 harmonizes data management and data protection standards within the WGGC. For this purpose, it compiles common guidelines concerning data management, data protection, and data privacy which all WGGC sites will adhere to. Furthermore, it actively pursues the standardization of data protection and data privacy policies within the next generation sequencing competence network. 

Data Management

The SIG 8 discusses and defines harmonized strategies for

  • Laboratory information management system (LIMS) to track project processing in the lab
  • Sample registration
  • Organization and automation of the data flow within the WGGC IT-infrastructure
  • Delivery of results to cooperation partners and users
  • Data archiving
  • Documentation and reporting

Data Protection

High data security and data privacy standards are mandatory when processing next generation sequencing data. The SIG 8 therefore makes recommendations and defines the WGGC standards for

  • Technical and organizational data protection measures
  • Implementation of data privacy regulations according to the EU-GDPR

Members

Leader: Susanne Motameny, UoC
Deputy leader: Peter Krawitz, UBO

Viktor Achter, UoC
Alexander Donath, UBO
Stefan Herms, UBO
Ulrich Lang, UoC
Holger Schwender, HHU
Harald Surowy, HHU
Holger Thiele, UoC

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